Soluble Guanylate Cyclase α1–Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma
نویسندگان
چکیده
Primary open angle glaucoma (POAG) is a leading cause of blindness worldwide. The molecular signaling involved in the pathogenesis of POAG remains unknown. Here, we report that mice lacking the α1 subunit of the nitric oxide receptor soluble guanylate cyclase represent a novel and translatable animal model of POAG, characterized by thinning of the retinal nerve fiber layer and loss of optic nerve axons in the context of an open iridocorneal angle. The optic neuropathy associated with soluble guanylate cyclase α1-deficiency was accompanied by modestly increased intraocular pressure and retinal vascular dysfunction. Moreover, data from a candidate gene association study suggests that a variant in the locus containing the genes encoding for the α1 and β1 subunits of soluble guanylate cyclase is associated with POAG in patients presenting with initial paracentral vision loss, a disease subtype thought to be associated with vascular dysregulation. These findings provide new insights into the pathogenesis and genetics of POAG and suggest new therapeutic strategies for POAG.
منابع مشابه
Soluble Guanylate Cyclase a1–Deficient Mice: a novel murine model for Primary Open Angle Glaucoma
Emmanuel S. Buys1*, Yu-Chieh Ko2,3, Clemens Alt4, Sarah R. Hayton1, Alexander Jones2, Laurel T. Tainsh1, Ruiyi Ren5, Andrea Giani6, Maeva Clerte’7, Emma Abernathy2, Robert E. T. Tainsh1, Dong-Jin Oh6, Rajeev Malhotra7, Pankaj Arora7, Nadine de Waard2, Binglan Yu1, Raphael Turcotte4,8, Daniel Nathan1, Marielle Scherrer-Crosbie7, Stephanie J. Loomis6, Jae H. Kang9, Charles P. Lin4, Haiyan Gong5, ...
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2013